Nonhuman Transferrin Receptor 1 Is an Efficient Cell Entry Receptor for Ocozocoautla de Espinosa Virus-Reference-Cited by-同舟云学术

Nonhuman Transferrin Receptor 1 Is an Efficient Cell Entry Receptor for Ocozocoautla de Espinosa Virus

Published:2013-12-15 Issue:24 Volume:87 Page:13930-13935
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Caì Yíngyún¹,Yú Shuĭqìng¹,Mazur Steven¹,Dŏng Lián²,Janosko Krisztina¹,Zhāng Téngfēi¹,Müller Marcel A.³,Hensley Lisa E.¹,Bavari Sina²,Jahrling Peter B.¹,Radoshitzky Sheli R.²,Kuhn Jens H.¹

Affiliation:

1. Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA

2. United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

3. Institute of Virology, University of Bonn Medical Centre, Bonn, Germany

Abstract

ABSTRACT Ocozocoautla de Espinosa virus (OCEV) is a novel, uncultured arenavirus. We found that the OCEV glycoprotein mediates entry into grivet and bat cells through transferrin receptor 1 (TfR1) binding but that OCEV glycoprotein precursor (GPC)-pseudotyped retroviruses poorly entered 53 human cancer cell lines. Interestingly, OCEV and Tacaribe virus could use bat, but not human, TfR1. Replacing three human TfR1 amino acids with their bat ortholog counterparts transformed human TfR1 into an efficient OCEV and Tacaribe virus receptor.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02701-13

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