Immunization of Mice with Virus-Like Vesicles of Kaposi Sarcoma-Associated Herpesvirus Reveals a Role for Antibodies Targeting ORF4 in Activating Complement-Mediated Neutralization-Reference-Cited by-同舟云学术

Immunization of Mice with Virus-Like Vesicles of Kaposi Sarcoma-Associated Herpesvirus Reveals a Role for Antibodies Targeting ORF4 in Activating Complement-Mediated Neutralization

Published:2023-02-28 Issue:2 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lam Alex K.¹^ORCID,Roshan Romin²,Miley Wendell²,Labo Nazzarena²,Zhen James³,Kurland Andrew P.⁴,Cheng Celine¹,Huang Haigen¹,Teng Pu-Lin¹,Harelson Claire¹,Gong Danyang¹,Tam Ying K.⁵,Radu Caius G.¹,Epeldegui Marta⁶,Johnson Jeffrey R.⁴,Zhou Z. Hong³^ORCID,Whitby Denise²,Wu Ting-Ting¹

Affiliation:

1. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California, USA

2. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

3. Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA

4. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

5. Acuitas Therapeutics, Vancouver, British Columbia, Canada

6. Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, California, USA

Abstract

KSHV is a virus that can lead to cancer after infection. A vaccine that prevents KSHV infection or transmission would be helpful in preventing the development of these cancers.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Dental and Craniofacial Research

W. M. Keck Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01600-22

Reference84 articles.

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3. Kaposi sarcoma: an analysis of the US and international experiences from the Israel Penn international transplant tumor registry

4. Correlates of Protection Induced by Vaccination

5. Janeway C, Travers P, Walport M. 2001. Immunobiology: the immune system in health and disease, 5th ed. Garland Science, New York, NY.

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