Increased Clinical Specificity with Ultrasensitive Detection of Clostridioides difficile Toxins: Reduction of Overdiagnosis Compared to Nucleic Acid Amplification Tests-Reference-Cited by-同舟云学术

Increased Clinical Specificity with Ultrasensitive Detection of Clostridioides difficile Toxins: Reduction of Overdiagnosis Compared to Nucleic Acid Amplification Tests

Published:2019-11 Issue:11 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sandlund Johanna¹,Estis Joel¹,Katzenbach Phoebe¹,Nolan Niamh¹,Hinson Kirstie²,Herres Jennifer²,Pero Troy²,Peterson Gwyn²,Schumaker Jeung-Mi²,Stevig Craig²,Warren Rhonda²,West Tsubasa²,Chow Siu-Kei²

Affiliation:

1. Singulex, Inc., Alameda, California, USA

2. Department of Microbiology, Laboratories Northwest, MultiCare Health System, Tacoma, Washington, USA

Abstract

Clostridioides difficile infection (CDI) is one of the most common health care-associated infections, resulting in significant morbidity, mortality, and economic burden. Diagnosis of CDI relies on the assessment of clinical presentation and laboratory tests. We evaluated the clinical performance of ultrasensitive single-molecule counting technology for detection of C. difficile toxins A and B.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00945-19

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