Nasal Immunization with Homogenate and Peptide Antigens Induces Protective Immunity against Trichinella spiralis-Reference-Cited by-同舟云学术

Nasal Immunization with Homogenate and Peptide Antigens Induces Protective Immunity against Trichinella spiralis

Published:2002-12 Issue:12 Volume:70 Page:7149-7152
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

McGuire Carolann¹,Chan Weng C.²,Wakelin Derek¹

Affiliation:

1. School of Life and Environmental Sciences

2. School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom

Abstract

ABSTRACT Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.12.7149-7152.2002

Reference20 articles.

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4. de Vos, T., G. Danell, and T. A. Dick. 1992. Trichinella spiralis: dose dependence and kinetics of the mucosal immune response in mice. Exp. Parasitol.75:99-111.

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