Generalized Immunological Decline during Long-Term Experimental Infection with Mycobacterium avium

Author:

Gilbertson Brad1,Cheers Christina1

Affiliation:

1. Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia

Abstract

ABSTRACT Terminal loss of immune responsiveness in C57BL/10 mice intranasally infected with Mycobacterium avium was observed in both spleen and lung. It was nonspecific and related to the duration of infection, not the age of the mice. While there was loss of total T cells, the remaining cells were less efficient at gamma interferon production.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference16 articles.

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