Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia-Reference-Cited by-同舟云学术

Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia

Published:2023-05-17 Issue:5 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

van der Veer Marlotte A. A.¹^ORCID,de Haan Timo R.²,Franken Linda G. W.¹,Hodiamont Caspar J.³,Groenendaal Floris⁴⁵,Dijk Peter H.⁶,de Boode Willem P.⁷,Simons Sinno⁸,Dijkman Koen P.⁹,van Straaten Henrica L. M.¹⁰,Rijken Monique¹¹,Cools Filip¹²,Nuytemans Debbie H. G. M.²,van Kaam Anton H.²,Bijleveld Yuma A.¹,Mathôt Ron A. A.¹,Brouwer Mieke J.,van den Broek Marcel P.,Rademaker Carin M. A.,Liem Djien,Steiner Katerina,Simons Sinno H. P.,Bos Annelies A.,Mulder-de Tollenaer S. M.,Jebbink-Akkerman L. J. M. Groot,Sonnaert Michel,Camfferman Fleur Anne

Affiliation:

1. Department of Hospital Pharmacology and Clinical Pharmacology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands

2. Department of Neonatology, Emma Children’s Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands

3. Medical Microbiology, Amsterdam University Medical Center, Amsterdam, The Netherlands

4. Department of Neonatology, Wilhelmina Children’s Hospital, Utrecht, The Netherlands

5. Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

6. University Medical Center Groningen, Beatrix Children’s Hospital, Department of Pediatrics, Division of Neonatology, University of Groningen, Groningen, The Netherlands

7. Department of Neonatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children’s Hospital, Nijmegen, The Netherlands

8. Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands

9. Department of Neonatology, Máxima Medical Center Veldhoven, Veldhoven, The Netherlands

10. Department of Neonatology, Isala Clinics, Zwolle, The Netherlands

11. Department of Neonatology, Leiden University Medical Center, Leiden, The Netherlands

12. Department of Neonatology, Vrije Universiteit Brussel, Brussels, Belgium

Abstract

Ceftazidime is an antibiotic commonly used to treat bacterial infections in term neonates undergoing controlled therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy after perinatal asphyxia. We aimed to describe the population pharmacokinetics (PK) of ceftazidime in asphyxiated neonates during hypothermia, rewarming, and normothermia and propose a population-based rational dosing regimen with optimal PK/pharmacodynamic (PD) target attainment.

Funder

ZonMw

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01707-22

Reference36 articles.

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2. Current and Emerging Therapies in the Management of Hypoxic Ischemic Encephalopathy in Neonates

3. Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment

4. Prediction of Drug Exposure in Critically Ill Encephalopathic Neonates Treated With Therapeutic Hypothermia Based on a Pooled Population Pharmacokinetic Analysis of Seven Drugs and Five Metabolites

5. Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy: a literature review

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