Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics-Reference-Cited by-同舟云学术

Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fang Yongliang¹,Kirsch Jack R.¹,Li Liang²,Brooks Seth A.¹,Heim Spencer¹,Tan Cynthia¹,Eszterhas Susan¹,Cheng Hao D.³,Zhao Hongliang¹,Xiong Yan Q.²,Griswold Karl E.¹³⁴^ORCID

Affiliation:

1. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA

2. The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA

3. Lyticon LLC, Lebanon, New Hampshire, USA

4. Stealth Biologics, LLC, Lebanon, New Hampshire, USA

Abstract

There is an urgent need for novel agents to treat drug-resistant bacterial infections, such as multidrug-resistant Staphylococcus aureus (MRSA). Desirable properties for new antibiotics include high potency, narrow species selectivity, low propensity to elicit new resistance phenotypes, and synergy with standard-of-care (SOC) chemotherapies.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01707-20

Reference63 articles.

1. The drug-resistant bacteria that pose the greatest health threats

2. O'Neill J. 2016. Tackling drug-resistant infections globally: final report and recommendations. Review on Antimicrobial Resistance, London, United Kingdom.

3. CDC. 2019. Antibiotic resistance threats in the United States 2019. Centers for Disease Control and Prevention Atlanta GA. http://www.cdc.gov/drugresistance/Biggest-Threats.html.

4. Treatment of MRSA soft tissue infections: An overview

5. When sepsis persists: a review of MRSA bacteraemia salvage therapy

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