Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs-Reference-Cited by-同舟云学术

Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs

Published:2008-12 Issue:12 Volume:52 Page:4466-4469
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Krivogorsky Bogdana¹,Grundt Peter²,Yolken Robert¹,Jones-Brando Lorraine¹

Affiliation:

1. Stanley Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland

2. Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota

Abstract

ABSTRACT New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti- Toxoplasma infection therapeutics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00903-08

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