Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis -Potentiated Hypoxic-Ischemic Brain Injury

Author:

Lai Jacqueline C. Y.123ORCID,Svedin Pernilla1,Ek C. Joakim1ORCID,Mottahedin Amin1,Wang Xiaoyang14,Levy Ofer235ORCID,Currie Andrew67ORCID,Strunk Tobias68,Mallard Carina14ORCID

Affiliation:

1. Center for Perinatal Medicine and Health, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

2. Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USA

3. Harvard Medical School, Harvard University, Boston, Massachusetts, USA

4. Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China

5. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA

6. Centre for Neonatal Research and Education, University of Western Australia, Perth, Western Australia, Australia

7. Medical, Molecular and Forensic Sciences, Murdoch University, Perth, Western Australia, Australia

8. Neonatal Directorate, King Edward Memorial Hospital for Women, Subiaco, Western Australia, Australia

Abstract

Infection is correlated with increased risk of neurodevelopmental sequelae in preterm infants. In modeling neonatal brain injury, Toll-like receptor agonists have often been used to mimic infections and induce inflammation. Using the most common cause of bacteremia in preterm infants, Staphylococcus epidermidis , we present a more clinically relevant neonatal mouse model that addresses the combined effects of bacterial infection together with subsequent hypoxic-ischemic brain insult.

Funder

VINNOVA VINNMER Marie-Curie

Wilhelm and Martina Lundgrens Foundation

Lilla Barnets Fund

Anna-Brita and Bo Castegrens Memorial Foundation

ALF-agreement

Leducq Foundation

Åhlen Foundation

Telethon Perth Children's Hospital Research Funds

Cerebral Palsy Alliance Australia

Swedish Research Council Formas

Torsten Söderbergs Stiftelse

STROKE-Riksförbundet

Hjärnfonden

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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