Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants-Reference-Cited by-同舟云学术

Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Demczuk Walter¹,Martin Irene¹,Sawatzky Pam¹,Allen Vanessa²,Lefebvre Brigitte³,Hoang Linda⁴,Naidu Prenilla⁵,Minion Jessica⁶,VanCaeseele Paul⁷,Haldane David⁸,Eyre David W.⁹¹⁰¹¹,Mulvey Michael R.¹

Affiliation:

1. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

2. Public Health Ontario Laboratories, Toronto, Ontario, Canada

3. Laboratoire de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Québec, Canada

4. British Columbia Centres for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver, British Columbia, Canada

5. Provincial Laboratory for Public Health, Edmonton, Alberta, Canada

6. Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada

7. Cadham Provincial Laboratory, Winnipeg, Manitoba, Canada

8. Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

9. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

10. National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom

11. Oxford National Institute for Health Research Health Protection Research Unit, Oxford, United Kingdom

Abstract

The emergence of Neisseria gonorrhoeae strains that are resistant to azithromycin and extended-spectrum cephalosporins represents a public health threat, that of untreatable gonorrhea infections. Multivariate regression modeling was used to determine the contributions of molecular antimicrobial resistance determinants to the overall antimicrobial MICs for ceftriaxone, cefixime, azithromycin, tetracycline, ciprofloxacin, and penicillin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02005-19

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