Affiliation:
1. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
Abstract
The extent to which erythrocytes are hemolyzed by Newcastle disease virus is a function of the relative concentrations of both virus and erythrocytes. Under proper conditions, the interaction of a single virus particle with an erythrocyte is sufficient to cause lysis. The extent of hemolysis is directly proportional to virus concentration only when the virus-erythrocyte ratio is very low. At the higher virus-erythrocyte ratios usually employed in hemolysis experiments, the extent of hemolysis is proportional to the logarithm of the virus concentration. Thus, quantitative comparisons of hemolytic activities of different virus preparations cannot be made by directly comparing the extent of hemolysis. Relative hemolytic activities must be determined by comparing virus concentrations which yield equivalent amounts of hemolysis (the quantitative comparison procedure).
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference11 articles.
1. Haemolysis by Newcastle disease virus. II. General character of haemolytic action;Burnet F. M.;Aust. J. Exp. Biol. Med. Sci.,1950
2. Etude cinetique de L hemolyse provoquee par Myxovirus parainfluenzae 1 (virus Sendai);Chabert A.;Ann. Inst. Pasteur,1964
3. Hemolytic interaction of Newcastle disease virus and chicken erythrocytes. II. Determining factors;Clavell L. A.;Applied Microbiol.,1972
4. Studies on the hemolytic activity of Newcastle disease virus (NDV);Granoff A.;J. Immunol.,1954
5. A Newcastle disease virus (NDV) hemolysin;Kilham L.;Proc. Soc. Exp. Biol. Med.,1949
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献