Establishment of an Active Laboratory-Based Surveillance for Bacterial Meningitis in Croatia and Molecular Characterization of Neisseria meningitidis Isolates Causing Meningococcal Disease That Were Collected in the Year 2000, the First Year of Activity

Author:

Boras A.1,Jeren T.1,Sacchi C. T.2,Schmink S.2,Bozinovic D.1,Barsic B.1,Rosenstein N. E.2,Popovic T.2

Affiliation:

1. University Hospital for Infectious Diseases, Zagreb, Croatia

2. Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

ABSTRACT In 2000, 23 Neisseria meningitidis (meningococcal [Men]) isolates were collected in Croatia through an active laboratory-based surveillance for bacterial meningitis (17 Men serogroup B [MenB], 4 MenC, 1 MenW135, and 1 nongroupable isolate). Molecular characterization revealed a substantial level of diversity with only six isolates belonging to electrophoretic type 5 (ET-5) and ET-37 hypervirulent complexes.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference19 articles.

1. Baygraves, J. A., and M. J. C. Maiden. 1992. Analysis of clonal relationships between strains of Neisseria meningitidis by pulsed-gel electrophoresis. J. Gen. Microbiol.138:523-531.

2. Boras A. B. Borcic T. Popovic D. Bozinovic B. Barsic and Members of the Croatian Study Group for Bacterial Meningitis. 2001. Meningococcal disease in the Republic of Croatia in the year 2000 p. 64-66. In Proceedings of the 6th Meeting of the European Monitoring Group on Meningococci Orebro Sweden.

3. Boras, A., B. Kaic, I. Ivic, S. Schmink, C. T. Sacchi, V. Polic-Punda, and T. Popovic. 2002. Molecular approaches to differentiation of W135 Neisseria meningitidis strains in Croatia. Clin. Infect. Dis.35:1451-1452.

4. Caugant, D. A. 1998. Population genetics and molecular epidemiology of Neisseria meningitidis.APMIS106:505-525.

5. Karelova E. V. Janculova and M. Slacikova. 2001. Analysis of epidemiological situation in invasive meningococcal disease in the Slovak Republic in 2000 p. 93-94. In Proceedings of the 6th Meeting of the European Monitoring Group on Meningococci Orebro Sweden.

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