Ultrastructural Effects of Oritavancin on Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus-Reference-Cited by-同舟云学术

Ultrastructural Effects of Oritavancin on Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus

Published:2009-02 Issue:2 Volume:53 Page:800-804
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Belley Adam¹,Harris Robert²,Beveridge Terry²,Parr Tom¹,Moeck Gregory¹

Affiliation:

1. Targanta Therapeutics, Inc., 7170 Frederick Banting, St. Laurent, Quebec, Canada

2. MicroTEM Inc., P.O. Box 1107, 101 Chalmers St., Elora, Ontario, Canada N0B 1S0

Abstract

ABSTRACT The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00603-08

Reference22 articles.

1. Allen, N. E., and T. I. Nicas. 2003. Mechanism of action of oritavancin and related glycopeptide antibiotics. FEMS Microbiol. Rev.26:511-532.

2. Effect of Polysorbate 80 on Oritavancin Binding to Plastic Surfaces: Implications for Susceptibility Testing

3. P827. 17th Eur. Congr. Clin. Microbiol. Infect. Dis. 2007

4. 47th Intersci. Conf. Antimicrob. Agents Chemother. 2007

5. P537. 18th Eur. Congr. Clin. Microbiol. Infect. Dis. 2008

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