Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety-Reference-Cited by-同舟云学术

Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety

Published:2019-08 Issue:8 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Crass Ryan L.¹^ORCID,Cojutti Pier Giorgio²³,Pai Manjunath P.¹^ORCID,Pea Federico²³

Affiliation:

1. Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA

2. Department of Medicine, University of Udine, Udine, Italy

3. Institute of Clinical Pharmacology, Santa Maria della Misericordia University Hospital of Udine, Udine, Italy

Abstract

Linezolid is administered as a fixed dose to all patients despite evidence of increased exposure and myelosuppression in renal impairment. The objectives of these studies were to assess the risk of thrombocytopenia with standard-dose linezolid in renal impairment and to identify an alternate dosing strategy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00605-19

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