Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages

Author:

Kwan Tony1,Liu Jing1,DuBow Michael2,Gros Philippe3,Pelletier Jerry3

Affiliation:

1. Targanta Therapeutics, Inc., 7170 Frederick Banting, 2nd Floor, Ville Saint Laurent, Quebec, Canada H4S 2A1;

2. Institut de Génétique et Microbiologie, Université Paris Sud, Bâtiment 409, 91405 Orsay, France

3. Department of Biochemistry and McGill Cancer Center, McIntyre Medical Sciences Building, McGill University, Montréal, Québec, Canada H3G 1Y6

Abstract

ABSTRACT A genomic analysis of 18 P. aeruginosa phages, including nine newly sequenced DNA genomes, indicates a tremendous reservoir of proteome diversity, with 55% of open reading frames (ORFs) being novel. Comparative sequence analysis and ORF map organization revealed that most of the phages analyzed displayed little relationship to each other.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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