Productive Replication of Human Adenoviruses in Mouse Epidermal Cells

Author:

Ganly Ian1,Mautner Vivien2,Balmain Allan1

Affiliation:

1. CRC Department of Medical Oncology, CRC Beatson Laboratories, Glasgow G61 1BD, Scotland,1 and

2. CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, England,2 United Kingdom

Abstract

ABSTRACT In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference23 articles.

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2. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells;Bischoff J. R.;Science,1996

3. Loss of heterozygosity and mutational alterations of the p53 gene in skin tumors of interspecific hybrid mice;Burns P. A.;Oncogene,1991

4. Infection of mouse liver by human adenovirus type 5;Duncan S. J.;J. Gen. Virol.,1978

5. Molecular biology of adenovirus type 2 semipermissive infections. I. Viral growth and expression of viral replicative functions during restricted adenovirus infection;Eggerding F. A.;Virology,1986

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