vanO, a New Glycopeptide Resistance Operon in Environmental Rhodococcus equi Isolates-Reference-Cited by-同舟云学术

vanO, a New Glycopeptide Resistance Operon in Environmental Rhodococcus equi Isolates

Published:2013-12-16 Issue:3 Volume:58 Page:1768-1770
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Gudeta Dereje Dadi,Moodley Arshnee,Bortolaia Valeria,Guardabassi Luca

Abstract

ABSTRACTWe describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) inRhodococcus equifrom soil. ThevanOoperon has low homology to enterococcalvanoperons and harbors avanHOXcluster transcribed in the direction opposite that of thevanS-vanRregulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treatR. equiinfections and resistance has been reported in clinical isolates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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