Effects of pH on the Activity of Ketoconazole Against Candida albicans-Reference-Cited by-同舟云学术

Effects of pH on the Activity of Ketoconazole Against Candida albicans

Published:1983-01 Issue:1 Volume:23 Page:105-107
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Minagawa Harushige¹,Kitaura Kozo¹,Nakamizo Nobuhiro¹

Affiliation:

1. Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., 1188, Shimotogari, Nagaizumicho, Suntogun, Shizuoka 411, Japan

Abstract

The activity of ketoconazole against Candida albicans in Sabouraud glucose medium was markedly influenced by pH. Minimum inhibitory concentrations of this imidazole against both a standard strain and clinical isolates ranged from 40 μg/ml at pH 3 to 0.02 μg/ml at pH 7, a greater than 1,000-fold difference.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.23.1.105

Reference11 articles.

1. Mechanism of action of antifungal drugs, with special reference to the imidazole derivatives;Borgera M.;Rev. Infect. Dis.,1980

2. Comparison of the in vitro antifungal activities of miconazole and a new imidazole, R41,400;Dixon D.;J. Infect. Dis.,1978

3. Studies on in vitro antimicrobial activity of miconazole. II. Various factors influencing its minimum inhibitory and cidal concentrations;Egawa A.;Jpn. J. Med. Mycol.,1978

4. Studies on in vitro antimicrobial activity of miconazole;Epwa A.;Jpn. J. Med. Mycol.,1977

5. Antimycotic imidazoles. Part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent;Heeres J.;J. Med. Chem.,1979

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