Presence of a neutralizing domain in isolates of rubella virus in Cordoba, Argentina-Reference-Cited by-同舟云学术

Presence of a neutralizing domain in isolates of rubella virus in Cordoba, Argentina

Published:1997-07 Issue:4 Volume:4 Page:493-495
ISSN:1071-412X
Container-title:Clinical Diagnostic Laboratory Immunology
language:en
Short-container-title:Clin Diagn Lab Immunol

Author:

Cordoba P¹,Grutadauria S L¹,Cuffini C¹,Zapata M T¹

Affiliation:

1. Instituto de Virología J. M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.

Abstract

We studied the presence of a neutralizing epitope of rubella virus (RV) in locally circulating strains in Cordoba, Argentina, using binding by the monoclonal antibody (MAb) H3. This epitope is contained in a sequence of the E1 glycoprotein (E1208-239) represented by the synthetic peptide SP15. H3 MAb showed specific binding to SP15 by enzyme-linked immunosorbent assay (ELISA). One wild-type postnatal isolate, four clones derived from this isolate, and one congenital isolate were reactive with H3 by ELISA. These results suggest that the region of RV represented by SP15 is a domain present in locally circulating strains.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/cdli.4.4.493-495.1997

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