In Vivo Pharmacodynamic Target Assessment of Antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Neutropenic Murine Pneumonia Model-Reference-Cited by-同舟云学术

In Vivo Pharmacodynamic Target Assessment of Antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Neutropenic Murine Pneumonia Model

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhou Yu-Feng¹²,Liu Ping¹²,Dai Shu-He¹²,Sun Jian¹²^ORCID,Liu Ya-Hong¹²³,Liao Xiao-Ping¹²^ORCID

Affiliation:

1. National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

2. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China

3. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, China

Abstract

We determined in vivo efficacy and target PK/PD exposures of antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in the murine pneumonia model. The mean plasma free drug area under the concentration-time curve/MIC ( f AUC/MIC) targets associated with stasis and 1-log 10 and 2-log 10 kill effects were 8.93, 19.2, and 48.1, respectively, for S. pneumoniae , whereas they were 30.

Funder

The National Key Research and Development Program of China

The Program for Innovative Research Team in the University of Ministry of Education of China

The Foundation for Innovation and Strengthening School Project of Guangdong, China

The Guangdong Special Support Program Innovation Team

The Innovation Team Project of Guangdong University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01354-20