SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

Author:

Nguyen Long C.1,Renner David M.23,Silva Diane4,Yang Dongbo1,Parenti Nicholas A.23,Medina Kaeri M.2,Nicolaescu Vlad56,Gula Haley56,Drayman Nir7,Valdespino Andrea1,Mohamed Adil7,Dann Christopher1,Wannemo Kristin4,Robinson-Mailman Lydia1,Gonzalez Alan4,Stock Letícia1,Cao Mengrui4,Qiao Zeyu8,Moellering Raymond E.8,Tay Savas7,Randall Glenn56,Beers Michael F.910,Rosner Marsha Rich1,Oakes Scott A.4,Weiss Susan R.23ORCID

Affiliation:

1. Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA

2. Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Department of Pathology, University of Chicago, Chicago, Illinois, USA

5. Department of Microbiology, University of Chicago, Chicago, Illinois, USA

6. Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, Illinois, USA

7. Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois, USA

8. Department of Chemistry, University of Chicago, Chicago, Illinois, USA

9. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

10. Penn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

SARS-CoV-2 is the third lethal respiratory coronavirus, after MERS-CoV and SARS-CoV, to emerge this century, causing millions of deaths worldwide. Other common coronaviruses such as HCoV-OC43 cause less severe respiratory disease.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Eye Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3