HIV-1 Genomes Are Enriched in Memory CD4 + T-Cells with Short Half-Lives

Author:

Morcilla Vincent1,Bacchus-Souffan Charline2,Fisher Katie13ORCID,Horsburgh Bethany A.13,Hiener Bonnie13,Wang Xiao Qian13,Schlub Timothy E.4,Fitch Mark5,Hoh Rebecca6,Hecht Frederick M.6,Martin Jeffrey N.6,Deeks Steven G.6,Hellerstein Marc K.5,McCune Joseph M.7,Hunt Peter W.2,Palmer Sarah13

Affiliation:

1. Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia

2. Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA

3. Sydney Medical School, Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

4. Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

5. Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, USA

6. Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA

7. Global Health Innovative Technology Solutions/HIV Frontiers, Bill & Melinda Gates Foundation, Seattle, Washington, USA

Abstract

The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and presumably replication-competent proviruses make up the latent HIV-1 reservoir.

Funder

HHS | National Institutes of Health

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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