Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species-Reference-Cited by-同舟云学术

Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Arce-Rodríguez Alejandro¹^ORCID,Pankratz Debbie²,Preusse Matthias¹,Nikel Pablo I.³^ORCID,Häussler Susanne¹²⁴⁵

Affiliation:

1. Department of Molecular Bacteriology, Helmholtz Centre for Infection Research, Braunschweig, Germany

2. Department of Molecular Bacteriology, Twincore, Hannover, Germany

3. The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark

4. Department of Clinical Microbiology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark

5. Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany

Abstract

The emergence of antibiotic resistance has become one of the major threats to public health. A better understanding of antimicrobial killing mechanisms promises to uncover new ways to resensitize bacteria to commonly used antibiotics.

Funder

ERC Consolidator

RESIST Cluster of Excellence

Deutsche Forschungsgemeinschaft

Novo Nordisk Fonden

Danish Council for Independent Research

H2020 European Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02434-21

Reference62 articles.

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5. A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics

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