Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein

Published:2000-10 Issue:10 Volume:68 Page:6066-6068
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Krall Rebecca¹,Schmidt Gudula²,Aktories Klaus²,Barbieri Joseph T.¹

Affiliation:

1. Medical College of Wisconsin, Microbiology and Molecular Genetics, Milwaukee, Wisconsin 53226,1 and

2. Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany2

Abstract

ABSTRACT Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.10.6066-6068.2000

Reference14 articles.

1. The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity;Adamo J. E.;Mol. Biol. Cell,1999

2. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases;Caron E.;Science,1998

3. The exoenzyme S regulon of Pseudomonas aeruginosa;Frank D. W.;Mol. Microbiol.,1997

4. The N-terminal domain of Pseudomonas aeruginosa is a GTPase-activating protein for Rho GTPases;Goehring U.-M.;J. Biol. Chem.,1999

5. Ras-related GTPases and the cytoskeleton;Hall A.;Mol. Biol. Cell,1992

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