Affiliation:
1. Biology Department, Bates College, Lewiston, Maine 04240,1 and
2. The Jackson Laboratory, Bar Harbor, Maine 046092
Abstract
ABSTRACT
Periodontal disease affects a large percentage of the human population. Resorption of the alveolar bone of the jaw is a pivotal sequela of periodontal disease, because this bone is the attachment site for the periodontal ligaments that anchor the teeth. Using a murine model in which alveolar bone loss is induced by oral infection with
Porphyromonas gingivalis
, a gram-negative bacterium associated with human adult periodontal disease, we provide evidence suggesting that susceptibility to such bone loss is a genetically determined trait. AKR/J, DBA/2J, and BALB/cByJ or BALB/cJ mice were highly susceptible, while A/J, A/HeJ, 129/J, SJL/J, and C57BL/6J mice were much more resistant. When susceptible BALB/cJ and BALB/cByJ mice were crossed to resistant strains, two patterns were observed. (BALBc/ByJ × C57BL/6J)F
1
offspring were susceptible, suggesting C57BL/6J has recessive resistance alleles, while (BALB/cJ × A/J)F
1
mice were all resistant, suggesting that A/J mice have dominant resistance alleles. These results suggest a tractable genetic basis for
P. gingivalis
-induced alveolar bone loss and open the possibility of exploiting the mouse model to identify loci important for host susceptibility and resistance to periodontal disease.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
134 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献