Cloned Schistosoma mansoni proteinase (hemoglobinase) as a putative serodiagnostic reagent

Author:

Chappell C L1,Hackel J1,Davis A H1

Affiliation:

1. Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030.

Abstract

Expressed cDNA encoding a proteolytic enzyme from Schistosoma mansoni has been cloned recently. Circulating antibodies reacting with the recombinant protein have been detected in the blood of mice and humans infected with S. mansoni, S. japonicum, or S. haematobium. S. mansoni and S. haematobium infection can be distinguished by antibody titer.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference11 articles.

1. Schistosoma mansoni: proteinase activity of "hemoglobinase;Chappell C. L.;Exp. Parasitol.,1986

2. Chappeil C. L. and M. H. Dresden. 1987. Purification of cysteine proteinases from adult Schistosoma mansoni. Arch. 198 NOTES

3. Chappeil C. L. and M. H. Dresden. 1987. Schistosoma mansoni adult worm proteinase: tissue localization in the parasite and antibody response in infected animals p. 399-408. In Molecular strategies of parasitic invasion. Alan R. Liss Inc. New York.

4. Antibody response to a purified parasite proteinase (SMw 32) in Schistosoma mansoni infected mice;Chappell C. L.;Am. J. Trop. Med. Hyg.,1988

5. Schistosome antigen workshop: summary of a meeting sponsored by the Edna McConnell Clark Foundation;Colley D. G.;J. Parasitol.,1983

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