A Matched Case-Case-Control Study of the Impact of Clinical Outcomes and Risk Factors of Patients with IMP-Type Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae in Japan

Author:

Saito Sho123ORCID,Hayakawa Kayoko12,Tsuzuki Shinya24,Ishikane Masahiro12,Nagashima Maki1,Mezaki Kazuhisa5,Sugiki Yuko6,Tajima Taichi2,Matsunaga Nobuaki2,Ide Satoshi13,Kinoshita Noriko123,Kusama Yoshiki23,Fujitomo Yumiko2,Nakamoto Takato1,Toda Yuta1,Kaku Mitsuo7,Kodama Eiichi N.8,Ohmagari Norio123

Affiliation:

1. Disease Control and Prevention Center, National Centre for Global Health and Medicine, Tokyo, Japan

2. AMR Clinical Reference Center, National Centre for Global Health and Medicine, Tokyo, Japan

3. Department of Emerging and Reemerging Infectious Diseases, Tohoku University School of Medicine, Sendai, Miyagi, Japan

4. Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

5. Microbiology Laboratory, National Center for Global Health and Medicine, Tokyo, Japan

6. Infection Control and Prevention, National Center for Global Health and Medicine, Tokyo, Japan

7. Department of Infection Control and Laboratory Diagnostics, Tohoku University School of Medicine, Sendai, Miyagi, Japan

8. Division of Infectious Diseases, School of Medicine, International Research Institute of Disaster Science, and Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

Abstract

IMP-type carbapenemase, found in various Gram-negative bacteria, has been increasingly detected worldwide. We aimed to study the outcomes and risk factors for acquisition of IMP-type carbapenemase-producing carbapenem-resistant Enterobacteriaceae (IMP-CRE), as this has not been evaluated in detail.

Funder

International Health Research from the Ministry of Health, Labor and Welfare of Japan

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference33 articles.

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2. World Health Organization. 2017. WHO publishes list of bacteria for which new antibiotics are urgently needed. https://www.who.int/news-room/detail/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed. Accessed 20 June 2019.

3. In-vivo loss of carbapenem resistance by extensively drug-resistant Klebsiella pneumoniae during treatment via porin expression modification

4. Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong

5. Carbapenemase genes and genetic platforms in Gram-negative bacilli: Enterobacteriaceae, Pseudomonas and Acinetobacter species

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