Sequences in Influenza A Virus PB2 Protein That Determine Productive Infection for an Avian Influenza Virus in Mouse and Human Cell Lines-Reference-Cited by-同舟云学术

Sequences in Influenza A Virus PB2 Protein That Determine Productive Infection for an Avian Influenza Virus in Mouse and Human Cell Lines

Published:2001-06 Issue:11 Volume:75 Page:5410-5415
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yao Yongxiu¹,Mingay Louise J.²,McCauley John W.³,Barclay Wendy S.¹

Affiliation:

1. School of Animal and Microbial Sciences, University of Reading, Reading, Berkshire RG6 6AJ,1

2. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE,2 and

3. Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN,3 United Kingdom

Abstract

ABSTRACT Reverse genetics was used to analyze the host range of two avian influenza viruses which differ in their ability to replicate in mouse and human cells in culture. Engineered viruses carrying sequences encoding amino acids 362 to 581 of PB2 from a host range variant productively infect mouse and human cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.11.5410-5415.2001

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