Peptides Corresponding to the Heptad Repeat Motifs in the Transmembrane Protein (gp41) of Human Immunodeficiency Virus Type 1 Elicit Antibodies to Receptor-Activated Conformations of the Envelope Glycoprotein-Reference-Cited by-同舟云学术

Peptides Corresponding to the Heptad Repeat Motifs in the Transmembrane Protein (gp41) of Human Immunodeficiency Virus Type 1 Elicit Antibodies to Receptor-Activated Conformations of the Envelope Glycoprotein

Published:2001-09-15 Issue:18 Volume:75 Page:8859-8863
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

de Rosny Eve¹,Vassell Russell¹,Wingfield Paul T.²,Wild Carl T.³,Weiss Carol D.¹

Affiliation:

1. Office of Vaccines, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA),1 and

2. Protein Expression Laboratory, National Institute of Arthritis and Musculosketal and Skin Diseases, National Institutes of Health,2Bethesda, and

3. Panacos Pharmaceuticals, Gaithersburg,3 Maryland

Abstract

ABSTRACT Two heptad repeat regions in the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane subunit (gp41) self-assemble into a six-helix bundle structure that is critical for virus entry. Immunizations with peptides corresponding to these regions generated antibodies specific to the receptor-activated conformations of gp41.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.18.8859-8863.2001

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