Plasmacytoid Dendritic Cells Are Highly Susceptible to Human Immunodeficiency Virus Type 1 Infection and Release Infectious Virus-Reference-Cited by-同舟云学术

Plasmacytoid Dendritic Cells Are Highly Susceptible to Human Immunodeficiency Virus Type 1 Infection and Release Infectious Virus

Published:2001-07-15 Issue:14 Volume:75 Page:6710-6713
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Patterson Steven¹,Rae Aaron²,Hockey Nicola²,Gilmour Jill¹,Gotch Frances¹

Affiliation:

1. Department of Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London SW10 9NH,1 and

2. Flow Cytometry Department, Imperial Cancer Research Fund, Lincolns Inn Field, London WC2 3PX,2 United Kingdom

Abstract

ABSTRACT Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.14.6710-6713.2001

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