Direct Ex Vivo Measurement of CD8 + T-Lymphocyte Responses to Human Parvovirus B19-Reference-Cited by-同舟云学术

Direct Ex Vivo Measurement of CD8 + T-Lymphocyte Responses to Human Parvovirus B19

Published:2001-01 Issue:1 Volume:75 Page:540-543
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tolfvenstam T.¹,Oxenius A.²,Price D. A.²,Shacklett B. L.³,Spiegel H. M. L.³,Hedman K.⁴,Norbeck O.¹,Levi M.⁵,Olsen K.²,Kantzanou M.²,Nixon D. F.³,Broliden K.¹,Klenerman P.²

Affiliation:

1. Department of Virology, Karolinska Institute, Stockholm, Sweden1;

2. Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom2;

3. Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 100163;

4. Department of Virology, Haartman Institute, University of Helsinki, SF-00014 Helsinki, Finland4; and

5. Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden5

Abstract

ABSTRACT Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8 + T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.1.540-543.2001

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