Pharmacokinetic Study of Rectal Artesunate in Children with Severe Malaria in Africa-Reference-Cited by-同舟云学术

Pharmacokinetic Study of Rectal Artesunate in Children with Severe Malaria in Africa

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fanello Caterina¹²^ORCID,Hoglund Richard M.¹²,Lee Sue J.¹²,Kayembe Daddy³,Ndjowo Pauline³,Kabedi Charlie³,Badjanga Benjamin B.³,Niamyim Phettree²,Tarning Joel¹²^ORCID,Woodrow Charles¹²,Gomes Melba⁴,Day Nick P.¹²,White Nicholas J.¹²,Onyamboko Marie A.³

Affiliation:

1. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

2. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

3. Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo

4. World Health Organization, Geneva, Switzerland

Abstract

When severe malaria is suspected in children, the WHO recommends pretreatment with a single rectal dose of artesunate before referral to an appropriate facility. This was an individually randomized, open-label, 2-arm, crossover clinical trial in 83 Congolese children with severe falciparum malaria to characterize the pharmacokinetics of rectal artesunate.

Funder

Li Ka Shing Foundation

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02223-20

Reference30 articles.

1. WHO. 2013. Management of severe malaria: a practical handbook, 3rd ed. World Health Organization, Geneva, Switzerland.

2. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial