Phage-Encoded Cationic Antimicrobial Peptide Required for Lysis-Reference-Cited by-同舟云学术

Phage-Encoded Cationic Antimicrobial Peptide Required for Lysis

Published:2022-01-18 Issue:1 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Holt Ashley¹²^ORCID,Cahill Jesse¹²,Ramsey Jolene¹²^ORCID,Martin Cody¹²^ORCID,O’Leary Chandler¹²,Moreland Russell¹²,Maddox Lori T.¹²^ORCID,Galbadage Thushara³,Sharan Riti³,Sule Preeti³,Cirillo Jeffrey D.³,Young Ry¹²^ORCID

Affiliation:

1. Center for Phage Technology, Texas A&M University, College Station, Texas, USA

2. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA

3. Department of Microbial Pathogenesis and Immunology, Texas A&M University Health, Bryan, Texas, USA

Abstract

We provide evidence that phiKT produces an antimicrobial peptide for outer membrane disruption during lysis. This protein, designated a disruptin, is a new paradigm for phage lysis and has no similarities to other known lysis genes.

Funder

Arnold and Mabel Beckman Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00214-21

Reference59 articles.

1. Phage Lysis: Multiple Genes for Multiple Barriers

2. Phage spanins: diversity, topological dynamics and gene convergence