Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old-Reference-Cited by-同舟云学术

Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Enimil Anthony¹²,Antwi Sampson¹²,Yang Hongmei³,Dompreh Albert¹,Alghamdi Wael A.⁴⁵^ORCID,Gillani Fizza S.⁶,Orstin Antoinette¹,Bosomtwe Dennis¹,Opoku Theresa¹,Norman Jennifer⁷,Wiesner Lubbe⁷^ORCID,Langaee Taimour⁸,Peloquin Charles A.⁵^ORCID,Court Michael H.⁹,Greenblatt David J.¹⁰,Kwara Awewura¹¹^ORCID

Affiliation:

1. Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana

2. Department of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

3. Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

4. Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia

5. Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, USA

6. Department of Medicine, The Miriam Hospital, Providence, Rhode Island, USA

7. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

8. Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida, Gainesville, Florida, USA

9. Program in Individualized Medicine, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA

10. Graduate Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA

11. Department of Medicine, College of Medicine and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA

Abstract

Nevirapine-based antiretroviral therapy (ART) is one of the limited options in HIV-infected children younger than 3 years old (young children) with tuberculosis (TB) coinfection. To date, there are insufficient data to recommend nevirapine-based therapy during first-line antituberculosis (anti-TB) therapy in young children. We compared nevirapine pharmacokinetics (PK) in HIV-infected young children with and without TB coinfection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00839-19

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1. Pharmacogenetic predictors of nevirapine pharmacokinetics in Ghanaian children living with HIV with or without TB coinfection;Infection, Genetics and Evolution;2021-08

2. Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review;Journal of Antimicrobial Chemotherapy;2020-08-12