Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells-Reference-Cited by-同舟云学术

Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells

Published:2021-08-17 Issue:9 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ahmed Maizbha U.¹²,Azad Mohammad A. K.²,Li Mengyao²,Creek Darren J.¹^ORCID,Han Meiling²^ORCID,Zhou Fanfan³,Chan Kim³^ORCID,Zhou Qi Tony⁴^ORCID,Velkov Tony⁵,Li Jian²^ORCID

Affiliation:

1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

2. Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia

3. School of Pharmacy, The University of Sydney, Camperdown, NSW, Australia

4. Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA

5. Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia

Abstract

Inhaled polymyxins are associated with toxicity in human lung epithelial cells that involves multiple apoptotic pathways. However, the mechanism of polymyxin-induced pulmonary toxicity remains unclear. This study aims to investigate polymyxin-induced metabolomic perturbations in human lung epithelial A549 cells.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00835-21

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