Mycobacterium abscessus Strain Morphotype Determines Phage Susceptibility, the Repertoire of Therapeutically Useful Phages, and Phage Resistance-Reference-Cited by-同舟云学术

Mycobacterium abscessus Strain Morphotype Determines Phage Susceptibility, the Repertoire of Therapeutically Useful Phages, and Phage Resistance

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Dedrick Rebekah M.¹,Smith Bailey E.¹,Garlena Rebecca A.¹,Russell Daniel A.¹^ORCID,Aull Haley G.¹,Mahalingam Vaishnavi¹,Divens Ashley M.¹,Guerrero-Bustamante Carlos A.¹,Zack Kira M.¹,Abad Lawrence¹,Gauthier Christian H.¹,Jacobs-Sera Deborah¹^ORCID,Hatfull Graham F.¹^ORCID

Affiliation:

1. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

Mycobacterium abscessus infections in cystic fibrosis patients are challenging to treat due to widespread antibiotic resistance. The therapeutic use of lytic bacteriophages presents a new potential strategy, but the great variation among clinical M. abscessus isolates demands determination of phage susceptibility prior to therapy.

Funder

HHS | National Institutes of Health

Cystic Fibrosis Foundation

Howard Hughes Medical Institute

Fowler Fund for Phage Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03431-20

Reference51 articles.