Prosthetic Valve Endocarditis and Bloodstream Infection Due to Mycobacterium chimaera

Author:

Achermann Yvonne1,Rössle Matthias2,Hoffmann Matthias3,Deggim Vanessa4,Kuster Stefan1,Zimmermann Dieter R.2,Bloemberg Guido4,Hombach Michael4,Hasse Barbara1

Affiliation:

1. Division of Infectious Diseases and Hospital Epidemiology, University and University Hospital Zurich, Zurich, Switzerland

2. Institute of Clinical Pathology, University and University Hospital Zurich, Zurich, Switzerland

3. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

4. Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

Abstract

ABSTRACT Prosthetic valve endocarditis (PVE) due to fast-growing nontuberculous mycobacteria (NTM) has been reported anecdotally. Reports of PVE with slowly growing NTM, however, are lacking. We present here one case of PVE and one case of bloodstream infection caused by Mycobacterium chimaera . Randomly amplified polymorphic DNA (RAPD)-PCR indicated a relatedness of the two M. chimaera strains. Both patients had heart surgery 2 years apart from each other. A nosocomial link was not detected.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference14 articles.

1. Mycobacterial prosthetic valve endocarditis;Bush LM;Curr. Infect. Dis. Rep,2010

2. Microbiological cultures of heart valves and valve tags are not valuable for patients without infective endocarditis who are undergoing valve replacement;Giladi M;Clin. Infect. Dis,1997

3. Proposal to elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp. nov;Tortoli E;Int. J. Syst. Evol. Microbiol,2004

4. National Committee for Clinical Laboratory Standards. 2003. Susceptibility testing of mycobacteria, nocardia, and other aerobic actinomycetes. Approved standard M24-A. National Committee for Clinical Laboratory Standards, Wayne, PA.

5. Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST;Lucke K;J. Antimicrob. Chemother,2012

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