In Vitro Activities of DU-1102, a New Trioxaquine Derivative, against Plasmodium falciparum Isolates-Reference-Cited by-同舟云学术

In Vitro Activities of DU-1102, a New Trioxaquine Derivative, against Plasmodium falciparum Isolates

Published:2001-06 Issue:6 Volume:45 Page:1886-1888
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Basco Leonardo K.¹,Dechy-Cabaret Odile²,Ndounga Mathieu¹,Meche Fleurette Solange¹,Robert Anne²,Meunier Bernard²

Affiliation:

1. Institut de Recherche pour le Développement-Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon,1 and

2. Laboratoire de Chimie de Coordination du CNRS, 31077 Toulouse Cedex 4, France2

Abstract

ABSTRACT The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum . There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.6.1886-1888.2001

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