In Vitro Activities of DU-1102, a New Trioxaquine Derivative, against Plasmodium falciparum Isolates

Author:

Basco Leonardo K.1,Dechy-Cabaret Odile2,Ndounga Mathieu1,Meche Fleurette Solange1,Robert Anne2,Meunier Bernard2

Affiliation:

1. Institut de Recherche pour le Développement-Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon,1 and

2. Laboratoire de Chimie de Coordination du CNRS, 31077 Toulouse Cedex 4, France2

Abstract

ABSTRACT The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum . There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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