A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant <i>Neisseria gonorrhoeae</i> and Other High-Threat Pathogens-Reference-Cited by-同舟云学术

A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant Neisseria gonorrhoeae and Other High-Threat Pathogens

Published:2022-09-20 Issue:9 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Park Steven¹,Russo Riccardo²,Westfall Landon³,Shrestha Riju²,Zimmerman Matthew¹,Dartois Veronique¹^ORCID,Kurepina Natalia¹,Kreiswirth Barry¹,Singleton Eric²,Li Shao-Gang²,Mittal Nisha²,Ahn Yong-Mo²,Bilotta Joseph²,Connolly Kristie L.⁴,Jerse Ann E.⁴,Freundlich Joel S.²⁵,Perlin David S.¹^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Division of Infectious Disease, Department of Medicine, and the Ruy V. Lourenco Center for the Study of Emerging and Reemerging Pathogens, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA

3. Southern Research, Infectious Disease Research, Birmingham, Alabama, USA

4. Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

5. Department of Pharmacology and Physiology, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA

Abstract

Drug-resistant Neisseria gonorrhoeae is a serious global health concern. New drugs are needed that can overcome existing drug resistance and limit the development of new resistances.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00414-22

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