Development, Characterization, and Standardization of a Nose-Only Inhalation Exposure System for Exposure of Rabbits to Small-Particle Aerosols Containing Francisella tularensis-Reference-Cited by-同舟云学术

Development, Characterization, and Standardization of a Nose-Only Inhalation Exposure System for Exposure of Rabbits to Small-Particle Aerosols Containing Francisella tularensis

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

O’Malley Katherine J.¹,Bowling Jennifer D.¹,Barry Eileen M.²,Hazlett Karsten R. O.³^ORCID,Reed Douglas S.¹^ORCID

Affiliation:

1. Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Center for Vaccine Development, University of Maryland, Baltimore, Maryland, USA

3. Department for Immunology & Microbial Diseases, Albany Medical College, Albany, New York, USA

Abstract

Inhalation of Francisella tularensis causes pneumonic tularemia in humans, a severe disease with a 30 to 60% mortality rate. The reproducible delivery of aerosolized virulent bacteria in relevant animal models is essential for evaluating medical countermeasures. Here we developed optimized protocols for infecting New Zealand White (NZW) rabbits with aerosols containing F. tularensis .

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00198-19

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