Pmorf0222 , a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2

Author:

Xu Tenglin1,Zheng Yating1,Liu Benjin1,Kou Mingxing1,Jiang Qian1,Liu Jiasen1,Kang Hongtao1,Yang Mingfa1ORCID,Guo Dongchun1,Qu Liandong1ORCID

Affiliation:

1. Division of Zoonosis of Natural Foci, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China

Abstract

Pasteurella multocida primarily causes hemorrhagic septicemia and pneumonia in poultry and livestock. Identification of the relevant virulence factors is therefore essential for understanding its pathogenicity. Pmorf0222 , encoding the PM0222 protein, is located on a specific prophage island of the pathogenic strain C48-1 of P. multocida .

Funder

MOST | National Key Research and Development Program of China

General Administration of Customs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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