Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence-Reference-Cited by-同舟云学术

Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Xiang Lucia¹²,Laranjeira-Silva Maria Fernanda¹³,Maeda Fernando Y.¹,Hauzel Jason¹,Andrews Norma W.¹,Mittra Bidyottam¹

Affiliation:

1. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA

2. Antibody Discovery and Protein Engineering, AstraZeneca, Gaithersburg, Maryland, USA

3. Department of Physiology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, SP, Brazil

Abstract

The molecular mechanisms underlying biological differences between two Leishmania species that cause cutaneous disease, L. major and L. amazonensis , are poorly understood. In L. amazonensis , reactive oxygen species (ROS) signaling drives differentiation of nonvirulent promastigotes into forms capable of infecting host macrophages.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00193-19

Reference51 articles.

1. WHO. 2010. Control of the leishmaniases. World Health Organization Technical Report Series. World Health Organization, Geneva, Switzerland.

2. The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages

3. Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis.