Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases

Author:

Ohsuka S1,Arakawa Y1,Horii T1,Ito H1,Ohta M1

Affiliation:

1. Department of Bacteriology, Nagoya University School of Medicine, Japan.

Abstract

The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5. However, the activities of PSE-2 and OXA-5 were greatly reduced at pH 5.8. All of the beta-lactamase inhibitors tested had poorer inhibitory activities at pH 5.8 than at pH 7.5 except clavulanic acid for TEM-1.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference20 articles.

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4. Classification of ~-lactamases: groups 2c, 2d, 2e, 3, and 4;Bush K.;Antimicrob. Agents Chemother.,1989

5. Kinetic interactions of tazobactam with ~-lactamase from all major structual classes;Bush K.;Antimicrob. Agents Chemother.,1993

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