Impaired Cytotoxic CD8 + T Cell Response in Elderly COVID-19 Patients

Author:

Westmeier Jaana1,Paniskaki Krystallenia2,Karaköse Zehra1,Werner Tanja1,Sutter Kathrin13,Dolff Sebastian2,Overbeck Marvin4,Limmer Andreas4,Liu Jia53,Zheng Xin53,Brenner Thorsten4,Berger Marc M.4,Witzke Oliver2,Trilling Mirko13ORCID,Lu Mengji13,Yang Dongliang53,Babel Nina678,Westhoff Timm9,Dittmer Ulf13,Zelinskyy Gennadiy13

Affiliation:

1. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

2. Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany

3. Joint International Laboratory of Infection and Immunity, HUST, Wuhan, China

4. Department of Anesthesiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

5. Department of Infectious Diseases, Union Hospital of Tonji Medical College, Huazhong University of Science and Technology, Wuhan, China

6. Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr–University Bochum, Herne, Germany

7. Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany

8. Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

9. Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr University of Bochum, Bochum, Germany

Abstract

Cytotoxic T cells are responsible for the elimination of infected cells and are key players in the control of viruses. CD8 + T cells with an effector phenotype express cytotoxic molecules and are able to perform target cell killing. COVID-19 patients with a mild disease course were analyzed for the differentiation status and cytotoxic profile of CD8 + T cells. SARS-CoV-2 infection induced a vigorous cytotoxic CD8 + T cell response. However, this cytotoxic profile of T cells was not detected in COVID-19 patients over the age of 80 years. Thus, the absence of a cytotoxic response in elderly patients might be a possible reason for the more frequent severity of COVID-19 in this age group than in younger patients.

Funder

Stiftung Universitätsmedizin Essen

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3