Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs

Author:

Fu Lifeng12,Shao Shuai3,Feng Yong1,Ye Fei4,Sun Xue56,Wang Qingling7,Yu Feng8,Wang Qisheng8,Huang Baoying4,Niu Peihua4,Li Xuebing1,Wong Catherine C. L.569,Qi Jianxun1ORCID,Tan Wenjie4,Gao George Fu1ORCID

Affiliation:

1. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

2. Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, China

3. National Institute for Radiological Protection, China CDC, Beijing, China

4. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China

5. Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, Beijing, China

6. Peking University First Hospital, Peking University, Beijing, China

7. Shaanxi Natural Carbohydrate Resource Engineering Research Center, College of Food Science and Technology, Northwest University, Xi’an, China

8. Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China

9. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China

Abstract

A TCM formula has played an important role in the treatment of COVID-19 in China. However, the mechanism of TCM action is still unclear.

Funder

CAS | Chinese Academy of Sciences Key Project

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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