Grass Carp Reovirus Induces Formation of Lipid Droplets as Sites for Its Replication and Assembly

Author:

He Libo12ORCID,Wang Qian12,Liang Xinyu12,Wang Hanyue12,Chu Pengfei3,Yang Cheng1,Li Yongming1,Liao Lanjie1,Zhu Zuoyan1,Wang Yaping14

Affiliation:

1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China

2. University of Chinese Academy of Sciences, Beijing, China

3. College of Animal Science and Technology, Yangzhou University, Yangzhou, China

4. Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China

Abstract

Grass carp reovirus (GCRV) is the most virulent pathogen in the genus Aquareovirus , which belongs to the family Reoviridae . GCRV-induced hemorrhagic disease is a major threat to the grass carp aquaculture industry.

Funder

Strategic Priority Program (A) of CAS

State Key Laboratory of Freshwater Ecology and Biotechnology

Youth Innovation Promotion Association of the Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference55 articles.

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3. Insights into the Antiviral Immunity against Grass Carp (Ctenopharyngodon idella) Reovirus (GCRV) in Grass Carp

4. Teleost-Specific TLR19 Localizes to Endosome, Recognizes dsRNA, Recruits TRIF, Triggers both IFN and NF-κB Pathways, and Protects Cells from Grass Carp Reovirus Infection

5. Autophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection

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