Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus-Reference-Cited by-同舟云学术

Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

van Rhijn Norman¹²^ORCID,Hemmings Sam¹,Storer Isabelle S. R.¹,Valero Clara¹³,Bin Shuraym Hajer¹,Goldman Gustavo H.³^ORCID,Gsaller Fabio¹⁴,Amich Jorge¹⁵,Bromley Michael J.¹²^ORCID

Affiliation:

1. Manchester Fungal Infection Group, Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

2. Antimicrobial Resistance Network, University of Manchester, Manchester, United Kingdom

3. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Ciências Farmacêuticas, Universidade de São Paulo, Ribeirão Preto, Brazil

4. Institute of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

5. Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain

Abstract

Aspergillosis is a spectrum of diseases and a major cause of morbidity and mortality. To treat these diseases, there are a few classes of antifungal drugs approved for clinical use.

Funder

Wellcome Trust

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02215-22

Reference50 articles.

1. Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision

2. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America