The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice-Reference-Cited by-同舟云学术

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

Published:2019-10-29 Issue:5 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kiouptsi Klytaimnistra¹,Jäckel Sven¹²,Pontarollo Giulia¹,Grill Alexandra¹²,Kuijpers Marijke J. E.³,Wilms Eivor¹,Weber Christian⁴⁵,Sommer Felix⁶^ORCID,Nagy Magdolna³,Neideck Carlos³⁴,Jansen Yvonne⁴,Ascher Stefanie¹,Formes Henning¹,Karwot Cornelia¹,Bayer Franziska¹,Kollar Bettina¹,Subramaniam Saravanan¹,Molitor Michael¹²⁷,Wenzel Philip¹²⁷,Rosenstiel Philip⁶,Todorov Hristo⁸,Gerber Susanne⁸,Walter Ulrich¹²,Jurk Kerstin¹²,Heemskerk Johan W. M.³,van der Vorst Emiel P. C.⁴⁵,Döring Yvonne⁴⁵⁹,Reinhardt Christoph¹²^ORCID

Affiliation:

1. Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany

2. German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Mainz, Germany

3. Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

4. Institute of Cardiovascular Prevention, Department of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany

5. German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany

6. Institute of Clinical Molecular Biology (IKMB), Kiel University, Kiel, Germany

7. Center for Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany

8. Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany

9. Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland

Abstract

Our results demonstrate a functional role for the commensal microbiota in atherothrombosis. In a ferric chloride injury model of the carotid artery, GF C57BL/6J mice had increased occlusion times compared to colonized controls. Interestingly, in late atherosclerosis, HFD-fed GF Ldlr −/− mice had reduced plaque rupture-induced thrombus growth in the carotid artery and diminished ex vivo thrombus formation under arterial flow conditions.

Funder

German Center for Cardiovascular Research

European Research Council

Cardiovascular Center MUMC+ Maastricht

EMBO Short Term Fellowship

Inneruniversitäre Forschungsförderung

Deutsche Forschungsgemeinschaft (DFG) Major Research Instrumentation Programme

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

American Society for Microbiology

Subject