Interleukin-10 Responses to Liver-Stage Antigen 1 Predict Human Resistance to Plasmodium falciparum-Reference-Cited by-同舟云学术

Interleukin-10 Responses to Liver-Stage Antigen 1 Predict Human Resistance to Plasmodium falciparum

Published:1999-07 Issue:7 Volume:67 Page:3424-3429
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kurtis Jonathan D.¹,Lanar David E.²,Opollo Malachi¹,Duffy Patrick E.¹

Affiliation:

1. U.S. Army Medical Research Unit-Kenya and Kenya Medical Research Institute, Kisumu, Kenya,1 and

2. Walter Reed Army Institute of Research, Washington, D.C.2

Abstract

ABSTRACT The design of an effective vaccine against Plasmodium falciparum , the most deadly malaria parasite of humans, requires a careful definition of the epitopes and the immune responses involved in protection. Liver-stage antigen 1 (LSA-1) is specifically expressed during the hepatic stage of P. falciparum and elicits cellular and humoral immune responses in naturally exposed individuals. We report here that interleukin-10 (IL-10) production in response to LSA-1 predicts resistance to P. falciparum after eradication therapy. Resistance was not related to gamma interferon or tumor necrosis factor alpha production. This is the first report that human IL-10 responses are associated with resistance after eradication therapy, and our findings support the inclusion of LSA-1 in a vaccine against malaria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.7.3424-3429.1999

Reference36 articles.

1. Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria;Aidoo M.;Lancet,1995

2. Plasmodium falciparum Incidence Relative to Entomologic Inoculation Rates at a Site Proposed for Testing Malaria Vaccines in Western Kenya

3. Characterization of malaria transmission by Anopheles (Diptera: Culicidae) in western Kenya in preparation for malaria vaccine trials;Beier J. C.;J. Med. Entomol.,1990

4. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes;Bouharoun-Tayoun H.;J. Exp. Med.,1990

5. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages;Bouharoun-Tayoun H.;J. Exp. Med.,1995

Cited by 68 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A comprehensive study of epitopes and immune reactivity among Plasmodium species;BMC Microbiology;2022-03-11

2. MODELLING AND STABILITY ANALYSIS OF IMMUNE REGULATORY MECHANISMS DURING MALARIA BLOOD STAGE INFECTION;Advances in Differential Equations and Control Processes;2021-02-02

3. Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria;Nature;2020-04-22

4. Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of Plasmodium falciparum LSA1 and LSAP2 for Efficacy against Liver-Stage Malaria;Infection and Immunity;2020-01-22

5. Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities;Malaria Journal;2019-12