Identification of a Pegivirus (GB Virus-Like Virus) That Infects Horses

Author:

Kapoor Amit1,Simmonds Peter2,Cullen John M.3,Scheel Troels K. H.45,Medina Jan L.1,Giannitti Federico6,Nishiuchi Eiko4,Brock Kenny V.7,Burbelo Peter D.8,Rice Charles M.4,Lipkin W. Ian1

Affiliation:

1. Center for Infection and Immunity, Columbia University, New York, New York, USA

2. Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom

3. North Carolina College of Veterinary Medicine, Raleigh, North Carolina, USA

4. Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, USA

5. Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, and Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

6. California Animal Health and Food Safety Laboratory, University of California—Davis, Davis, California, USA

7. Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA

8. Clinical Dental Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA

Abstract

ABSTRACT The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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